Facilities for Simulating from ODE-Based Models

Facilities for running simulations from ordinary differential equation (ODE) models, such as pharmacometrics and other compartmental models. A compilation manager translates the ODE model into C, compiles it, and dynamically loads the object code into R for improved computational efficiency. An event table object facilitates the specification of complex dosing regimens (optional) and sampling schedules. NB: The use of this package requires both C and Fortran compilers, for details on their use with R please see Section 6.3, Appendix A, and Appendix D in the "R Administration and Installation" manual. Also the code is mostly released under GPL. The VODE and LSODA are in the public domain. The information is available in the inst/COPYRIGHTS.


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Reference manual

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install.packages("RxODE")

0.7.2-1 by Wenping Wang, 3 days ago


https://www.r-project.org, https://github.com/nlmixrdevelopment/RxODE


Report a bug at https://github.com/nlmixrdevelopment/RxODE/issues


Browse source code at https://github.com/cran/RxODE


Authors: Matthew L. Fidler [aut], Melissa Hallow [aut], Wenping Wang [aut, cre], Zufar Mulyukov [ctb], Justin Wilkins [ctb], Simon Frost [ctb], Heng Li [ctb], Yu Feng [ctb], Alan Hindmarsh [ctb], Linda Petzold [ctb], Ernst Hairer [ctb], Gerhard Wanner [ctb], J Colinge [ctb], Hadley Wickham [ctb], G Grothendieck [ctb], Robert Gentleman [ctb], Ross Ihaka [ctb], R core team [cph], odepack authors [cph]


Documentation:   PDF Manual  


Task views: Analysis of Pharmacokinetic Data


GPL (>= 2) license


Imports utils, methods, digest, rex, dparser, brew, memoise, magrittr, Rcpp, inline, Matrix, R.utils, PreciseSums, mvnfast, cli, crayon, n1qn1

Suggests knitr, nlme, shiny, tcltk, testthat, devtools, covr, rmarkdown, SnakeCharmR, rSymPy, dplyr, tidyr, tibble, curl, ggplot2, gridExtra, microbenchmark, scales, stringi, htmltools

Linking to dparser, Rcpp, RcppArmadillo, PreciseSums


Depended on by nlmixr.


See at CRAN