Group Sequential Design

Derives group sequential designs and describes their properties.


3.0-1, January, 2016

  • More changes to comply with R standards (in NAMESPACE - importFrom statements - and DESCRIPTION - adding plyr to imports) ensuring appropriate references.
  • Deleted link in documentation that no longer exists (gsBinomialExact.Rd).

3.0-0, December, 2015

  • Updated xtable extension to meet R standards for extensions.
  • Fixed xtable.gsSurv and print.gsSurv to work with 1-sided designs
  • Update to calls to ggplot to replace show_guide (deprecated) with show.legend arguments where used in geom_text (function from ggplot2 package) calls; no user impact
  • Minor typo fixed in sfLogistic help file
  • Cleaned up "imports" and "depends" in an effort to be an R "good citizen"
  • Registered S3 methods in NAMESPACE


  • Minor edit to package description to comply with R standards

2.9-3, November, 2014

  • Added sfTrimmed as likely preferred spending function approach to skipping early or all interim efficacy analyses; this also can adjust bound when final analysis is performed with less than maximum planned information. Updated help(sfTrimmed) to demonstrate these capabilities.
  • Added sfGapped, which is primarily intended to eliminate futility analyses later in a study; see help(sfGapped) for an example
  • Added summary.spendfn to provide textual summary of spending functions; this simplified the print function for gsDesign objects
  • Added sfStep which can be used to set an interim spend when the exact amount of information is unknown; an example of how this can be misused is provided in the help file.
  • Fixed rounding so that gsBoundSummary, xtable.gsSurv and summary.gsDesign are consistent for gsSurv objects

Reference manual

It appears you don't have a PDF plugin for this browser. You can click here to download the reference manual.


3.2.0 by Keaven Anderson, 2 months ago

Browse source code at

Authors: Keaven Anderson [aut, cre]

Documentation:   PDF Manual  

Task views: Clinical Trial Design, Monitoring, and Analysis, Design of Experiments (DoE) & Analysis of Experimental Data

GPL (>= 3) license

Imports stats, magrittr, rlang, methods, graphics, tools, dplyr, tidyr, xtable

Depends on ggplot2

Suggests knitr, scales, rmarkdown, gt, testthat, covr, gridExtra, tibble, utils, mvtnorm

Depended on by coprimary, gsbDesign.

Suggested by ADCT, gscounts, ph2bye, ph2mult.

See at CRAN