Phase II Clinical Trial Design for Multinomial Endpoints

Provide multinomial design methods under intersection-union test (IUT) and union-intersection test (UIT) scheme for Phase II trial. The design types include : Minimax (minimize the maximum sample size), Optimal (minimize the expected sample size), Admissible (minimize the Bayesian risk) and Maxpower (maximize the exact power level).


Reference manual

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0.1.1 by Yalin Zhu, 5 years ago

Browse source code at

Authors: Yalin Zhu , Rui Qin

Documentation:   PDF Manual  

GPL (>= 2) license

Imports clinfun, graphics, stats

Suggests gsDesign, survival

See at CRAN