Calculation for Single Arm Group Sequential Test with Binary Endpoint

Consider an at-most-K-stage group sequential design with only an upper bound for the last analysis and non-binding lower bounds.With binary endpoint, two kinds of test can be applied, asymptotic test based on normal distribution and exact test based on binomial distribution. This package supports the computation of boundaries and conditional power for single-arm group sequential test with binary endpoint, via either asymptotic or exact test. The package also provides functions to obtain boundary crossing probabilities given the design.


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0.0.1 by Lei Wang, 2 years ago

Browse source code at

Authors: Lei Wang [aut, cre, cph] , BeiGene , Ltd. (Nasdaq: BGNE , HKEX: 06160) [cph]

Documentation:   PDF Manual  

GPL-3 license

Imports methods, mvtnorm, stats

See at CRAN