Frequentist sequential meta-analysis based on
'Trial Sequential Analysis' (TSA) in programmed in Java by the Copenhagen
Trial Unit (CTU). The primary function is the calculation of group
sequential designs for meta-analysis to be used for planning and analysis of
both prospective and retrospective sequential meta-analyses to preserve
type-I-error control under sequential testing. 'RTSA' includes tools for
sample size and trial size calculation for meta-analysis and core
meta-analyses methods such as fixed-effect and random-effects models and
forest plots. TSA is described in Wetterslev et. al (2008)
RTSA is a R package for sequential meta-analysis using Trial Sequential Analysis (TSA).
You can install the released version of RTSA from CRAN with:
install.packages("RTSA")
RTSA is the R version of TSA, originally being developed as a java stand-alone software. The RTSA manual is heavily inspired by the user manual for TSA by Kristian Thorlund, Janus Engstrøm, Jørn Wetterslev, Jesper Brok,
Georgina Imberger, and Christian Gluud. To access the original TSA software developed by Copenhagen Trial Unit please go to: https://ctu.dk/tsa/.
Copenhagen Trial Unit
Centre for Clinical Intervention Research
Department 3344, Rigshospitalet
DK-2100 Copenhagen Ø
Denmark
Tel. +45 3545 7171 Fax +45 3545 7101
E-mail: [email protected]