Adaptive Design in Clinical Trials

Existing adaptive design methods in clinical trials. The package includes power, stopping boundaries (sample size) calculation functions for two-group group sequential designs, adaptive design with coprimary endpoints, biomarker-informed adaptive design, etc.


Reference manual

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0.1.0 by Yalin Zhu, 4 years ago

Browse source code at

Authors: Yalin Zhu

Documentation:   PDF Manual  

GPL (>= 2) license

Imports stats, mvtnorm

Suggests clinfun, gsDesign

See at CRAN