Nonlinear Mixed Effects Models in Population Pharmacokinetics and Pharmacodynamics

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 ).


Reference manual

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1.0.0-7 by Wenping Wang, 8 months ago

Browse source code at

Authors: Matthew Fidler [aut] , Yuan Xiong [aut] , Rik Schoemaker [aut] , Justin Wilkins [aut] , Mirjam Trame [aut] , Teun Post [aut] , Robert Leary [ctb] , Wenping Wang [aut, cre] , Hadley Wickham [ctb] , Dirk Eddelbuettel [cph] , David Ardia [cph] , Katharine Mullen [cph]

Documentation:   PDF Manual  

Task views: Analysis of Pharmacokinetic Data

GPL (>= 2) license

Imports Rcpp, brew, lattice, parallel, lbfgs, dparser, methods, ggplot2, memoise, rex, minqa, Matrix, numDeriv, R.utils, n1qn1, PreciseSums, fastGHQuad, crayon, cli, RcppArmadillo, vpc, RxODE, nlme, magrittr, tidyr

Suggests knitr, rmarkdown, dplyr, data.table, lbfgsb3, testthat, madness, devtools, expm, matrixcalc, reshape2, nloptr, ucminf

Linking to dparser, Rcpp, RcppEigen, StanHeaders, BH

See at CRAN