Nonlinear Mixed Effects Models in Population Pharmacokinetics and Pharmacodynamics

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 ).


Reference manual

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1.1.1-9 by Wenping Wang, 3 months ago

Browse source code at

Authors: Matthew Fidler [aut] , Yuan Xiong [aut] , Rik Schoemaker [aut] , Justin Wilkins [aut] , Richard Hooijmaijers [aut] , Teun Post [aut] , Wenping Wang [aut, cre] , Robert Leary [ctb] , Mirjam Trame [ctb] , Hadley Wickham [ctb] , Dirk Eddelbuettel [cph] , Johannes Pfeifer [ctb] , Robert B. Schnabel [ctb] , Elizabeth Eskow [ctb] , Emmanuelle Comets [ctb] , Audrey Lavenu [ctb] , Marc Lavielle [ctb] , David Ardia [cph] , Bill Denney [ctb] , Daniel C. Dillon [ctb] , Katharine Mullen [cph] , Ben Goodrich [ctb]

Documentation:   PDF Manual  

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GPL (>= 2) license

Imports Rcpp, brew, parallel, methods, ggplot2, memoise, Matrix, n1qn1, fastGHQuad, cli, RcppArmadillo, RxODE, nlme, magrittr, tidyr, generics, flextable, stringr, yaml

Suggests knitr, rmarkdown, dplyr, tibble, data.table, lbfgsb3c, testthat, madness, devtools, expm, matrixcalc, reshape2, nloptr, ucminf, Rvmmin, broom.mixed, dotwhisker, officer, pkgdown, gridExtra, xpose, lotri, rex, minqa, lattice, digest, sys, crayon, lbfgs, dparser, vpc, huxtable

Linking to dparser, RxODE, RcppEigen, lbfgsb3c, Rcpp, BH, StanHeaders

Suggested by ggPMX.

See at CRAN