Nonlinear Mixed Effects Models in Population Pharmacokinetics and Pharmacodynamics

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'RxODE' package (Wang, Hallow, and James 2015 ).


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install.packages("nlmixr")

1.1.1-3 by Wenping Wang, a month ago


https://github.com/nlmixrdevelopment/nlmixr


Browse source code at https://github.com/cran/nlmixr


Authors: Matthew Fidler [aut] , Yuan Xiong [aut] , Rik Schoemaker [aut] , Justin Wilkins [aut] , Mirjam Trame [aut] , Richard Hooijmaijers [aut] , Teun Post [aut] , Robert Leary [ctb] , Wenping Wang [aut, cre] , Hadley Wickham [ctb] , Dirk Eddelbuettel [cph] , Johannes Pfeifer [ctb] , Robert B. Schnabel [ctb] , Elizabeth Eskow [ctb] , Emmanuelle Comets [ctb] , Audrey Lavenu [ctb] , Marc Lavielle [ctb] , David Ardia [cph] , Bill Denney [ctb] , Daniel C. Dillon [ctb] , Katharine Mullen [cph] , Ben Goodrich [ctb]


Documentation:   PDF Manual  


Task views: Analysis of Pharmacokinetic Data


GPL (>= 2) license


Imports Rcpp, brew, lattice, parallel, lbfgs, dparser, methods, ggplot2, memoise, rex, minqa, Matrix, R.utils, n1qn1, fastGHQuad, crayon, cli, RcppArmadillo, vpc, RxODE, nlme, magrittr, tidyr, sys, generics, huxtable, digest, flextable, stringr, yaml

Suggests knitr, rmarkdown, dplyr, data.table, lbfgsb3c, testthat, madness, devtools, expm, matrixcalc, reshape2, nloptr, ucminf, Rvmmin, broom.mixed, dotwhisker, officer, pkgdown, gridExtra, xpose, drake

Linking to dparser, RxODE, RcppEigen, lbfgsb3c, Rcpp, BH, StanHeaders


Suggested by ggPMX.


See at CRAN