Mixed Effects Cox Models

This package fits Cox proportional hazards models containing both fixed and random effects. The random effects can have a general form, of which familial interactions (a "kinship" matrix) is a particular special case. Note that the simplest case of a mixed effects Cox model, i.e. a single random per-group intercept, is also called a "frailty" model. The approach is based on Rippatti and Palgren, Biometrics 2002.


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install.packages("coxme")

2.2-14 by Terry M. Therneau, 20 days ago


Browse source code at https://github.com/cran/coxme


Authors: Terry M. Therneau [aut, cre]


Documentation:   PDF Manual  


Task views: Survival Analysis


LGPL-2 license


Imports nlme, Matrix

Depends on survival, methods, bdsmatrix

Suggests mvtnorm, kinship2

Linking to bdsmatrix


Imported by KMgene, MAGNAMWAR, MXM, RVFam, StatCharrms, famSKATRC, jstable, mlmm.gwas, seqMeta.

Depended on by GWAF.

Suggested by AICcmodavg, car, gap, insight, multcomp, pammtools.

Enhanced by MuMIn, emmeans.


See at CRAN