Mixed Effects Cox Models

Fit Cox proportional hazards models containing both fixed and random effects. The random effects can have a general form, of which familial interactions (a "kinship" matrix) is a particular special case. Note that the simplest case of a mixed effects Cox model, i.e. a single random per-group intercept, is also called a "frailty" model. The approach is based on Ripatti and Palmgren, Biometrics 2002.


Reference manual

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2.2-16 by Terry M. Therneau, 7 months ago

Browse source code at https://github.com/cran/coxme

Authors: Terry M. Therneau [aut, cre]

Documentation:   PDF Manual  

Task views: Survival Analysis

LGPL-2 license

Imports nlme, Matrix

Depends on survival, methods, bdsmatrix

Suggests mvtnorm, kinship2

Linking to bdsmatrix

Imported by MAGNAMWAR, MXM, RVFam, StatCharrms, coxmeg, famSKATRC, jstable, mlmm.gwas.

Suggested by AICcmodavg, car, finalfit, gap, insight, multcomp, tram, tramME.

Enhanced by MuMIn, emmeans.

See at CRAN