Inference in Randomized Controlled Trials with Death and Missingness

In randomized studies involving severely ill patients, functional outcomes are often unobserved due to missed clinic visits, premature withdrawal or death. It is well known that if these unobserved functional outcomes are not handled properly, biased treatment comparisons can be produced. In this package, we implement a procedure for comparing treatments that is based on the composite endpoint of both the functional outcome and survival. The procedure was proposed in Wang et al. (2016) . It considers missing data imputation with a sensitivity analysis strategy to handle the unobserved functional outcomes not due to death.


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3.0 by Chenguang Wang, 3 months ago

Browse source code at

Authors: Chenguang Wang [aut, cre], Andrew Leroux [aut, cre], Elizabeth Colantuoni [aut], Daniel O Scharfstein [aut], Trustees of Columbia University [cph] (tools/make_cpp.R, R/stanmodels.R)

Documentation:   PDF Manual  

GPL (>= 3) license

Imports sqldf, survival, parallel, methods

Depends on Rcpp, rstan

Suggests knitr, shiny, rmarkdown, pander, DT, shinythemes

Linking to StanHeaders, rstan, BH, Rcpp, RcppEigen

See at CRAN