In a clinical trial, it frequently occurs that the most credible outcome to evaluate the effectiveness of a new therapy (the true endpoint) is difficult to measure. In such a situation, it can be an effective strategy to replace the true endpoint by a (bio)marker that is easier to measure and that allows for a prediction of the treatment effect on the true endpoint (a surrogate endpoint). The package 'Surrogate' allows for an evaluation of the appropriateness of a candidate surrogate endpoint based on the meta-analytic, information-theoretic, and causal-inference frameworks. Part of this software has been developed using funding provided from the European Union's Seventh Framework Programme for research, technological development and demonstration under Grant Agreement no 602552.
Changes in version 0.2 - 1.1 o Added functions PPE.BinBin, comb27.BinBin, ECT, SPF.BinCont, Bootstrap.MEP.BinBin, PROC.BinBin, plot.PPE.BinBin.R o Dataset CIGTS_BinCont added
Changes in version 0.1.80 o ICA.ContCont.MultS, ICA.ContCont.MultS_alt and AA.Mult added o Typo corrected in Pred.TrialT.ContCont() function (thanks to Maria C. for reporting the typo)
Changes in version 0.1.73 - 0.1.79 o Fano.BinBin added o Changes in the function MarginalProbs, summary() has been added for object of class FixedDiscrDiscrIT o Typos corrected in manual o Option Histograms.Counterfactuals added in function CausalDiagramContCont() o Option Histograms.Correlations added in function CausalDiagramBinBin() o The function MaxEntContCont was added
Changes in version 0.1.72 o The function ICA.BinCont has been added
Changes in version 0.1-68 - 0.1-71
o The functions FixedDiscDiscrIT, ICA.BinBin.Grid.Sample.Uncert and Plot.FixedDiscrDiscrIT have been added o Corrected typos
Changes in version 0.1-65-0.1-67
o The functions MaxEntICABinBin and MaxEntSPFBinBin have been added o Corrected typos
Changes in version 0.1-64
o Corrected typos, changes in function TrialLevelMA
Changes in version 0.1-63
o Corrected typos, functions Prentice, TrialLevelIT, SurvSurvIT, FixedBinBinIT, FixedContBinIT, FixedBinContIT, and PredTrialTContCont added
Changes in version 0.1-62
o Corrected typos, updated namespace, functions TrialLevelContCont and TwoStageSurvSurv added
Changes in version: Surrogate_0.1-6
o The function Test.Mono has been added o Changes in plot and summary functions of ICA.BinBin, ICA.BinBin.Grid.Full, and ICA.BinBin.Grid.Sample
Changes in version: Surrogate_0.1-5
o The functions SPP.BinBin, ICA.Sample.ContCont, and ICA.BinBin.CounterAssum have been added
Changes in version: Surrogate_0.1-4
o The functions CausalDiagramBinBin, Restrictions.BinBin, ICA.BinBin.Grid.Full, and ICA.BinBin.Grid.Sample have been added
Changes in version: Surrogate_0.1-3
o Corrected typos
Changes in version: Surrogate_0.1-2
o The functions ICA.BinBin, MarginalProbs, RandVec, Sim.Data.CounterfactualsBinBin, and Sim.Data.CounterfactualsBinBin have been added
Changes in version: Surrogate_0.1-1
o The function CausalDiagramContCont has been added
o corrected some typos in .Rd files.