Optimal experimental designs for both population and individual
studies based on nonlinear mixed-effect models. Often this is based on a
computation of the Fisher Information Matrix. This package was developed
for pharmacometric problems, and examples and predefined models are available
for these types of systems. The methods are described in Nyberg et al.
PopED computes optimal experimental designs for both population and individual studies based on nonlinear mixed-effect models. Often this is based on a computation of the Fisher Information Matrix (FIM).
You need to have R installed. Download the latest version of R from www.r-project.org. Install PopED in R using one of the following methods:
install_github()approach requires that you build from source, i.e.
makeand compilers must be installed on your system -- see the R FAQ for your operating system; you may also need to install dependencies manually.
To get started you need to define
Learn more in this introduction to PopED
You are welcome to:
New and improved vignettes (#30, @giulialestini)!
Added power evaluation script to test the power of a design to identify a prameter different
than an assumed value. The function also calculates the number of individuals needed in a design to have a specific
?evaluate_power for more information (#26, @martin-gmx).
Added function to compute expected shrinkage of a design. See
?shrinkage for more information.
Updated and added new example scripts in
system.file("examples", package="PopED") (). This includes an example describing
how to handle covariate distributions in optimal design, an example on how to incorporate IOV, an example on how to handle shrinkage, an example with a full covariance matrix and an example with a prior FIM (#30, @giulialestini and @martin-gmx).
Major overhaul in optimization methods used in
poped_optim() so that generic optimization routines like
optim() can be easily used in optimizing PopED designs.
Update speed of FIM calculations (#20, @martin-gmx).
Update RSE calculations so that prior FIM is handled correctly (#22, @martin-gmx).
Simplified code and removed duplicated code (#21, #24 and #32, @martin-gmx).
New ways of handling inverting matricies, should be faster and work better when the matricies are ill-conditioned. See
?inv for more information (#19, @martin-gmx).
Updated functionality of IOV calculations.
optim_ARS() for when to stop search.
Extended functionality of
plot.model.prediction() (#23, @martin-gmx).
Bug fixing. See https://github.com/andrewhooker/PopED/commits/master for more information.
summary method for the results of
poped_optim in the PopED NAMESPACE, so that the method can actually be used! Just use
Fixed some old bugs that used
return as a varible in functions, a la MATLAB.
Added a vignette to introduce PopED!
Improved optimization with
poped_optim, plus all example scripts now running with
Update to more easily allow discrete optimization of xt and a variables. See the example scripts.
Added a summary method for the results of
poped_optim. Just use
changed handling of seed numbers in optimizations.
more robust handling of non-population models
more natural handling of NA values in design vectors
NAMESPACE: removed ggplot2 from "Depends" and added to "Imports"
Added mean line to efficiency plots.
Update to computation and error handling for Laplace approximation to ED objective function.
Added more intuitive cost function input. See examples in
Various small changes and bug fixes.
Added new optimization methods and tools, see
?poped_optim(). This function incorporates the new optimization routines
optim_LS which are optimized versions of previous optimization algorithms used in PopED. Both can be run with parallelization.
poped_optim() also incorporates the genetic algorithm from
GA::ga(), which can also be run with parallelization, and the "L-BFGS-B" method from
poped_optim() should be more efficient and faster than
Changed the default objective function to be the log of the determinant of the FIM.
Various small changes and bug fixes.
plot_efficiency_of_windows() bug that had wrong headers on each subplot.
Fixed bug in
plot_model_prediction() that did not plot the optimized design, but instead the initial design
Reorganized the database created from
create.poped.database(). The output from this function is now a list with 5 sub-lists: design, design_space, model, parameters and settings. Also removed duplicate entries in the database for easier manipulation. This will cause some back compatibility issues when refering to elements in a database.
Added example 10 describing a PKPD design of hepatitis C virus (HCV) kinetics to the
system.file("examples",package="PopED") directory of the PopED installation.
Updated model_prediction() to allow for creation of NONMEM datasets.
Useful for testing of optimized designs via PsN's (http://psn.sf.net) SSE tool, for example.
Two new functions create_design() and create_design_space() that allow for design and design space creation without the need for a model or parameter values.
Updated the create.poped.database() function to use create_design() and create_design_space()
Added examples for evaluation and optimization of a one-target quasi-steady-state target mediated drug disposition model (TMDD) to the system.file("examples",package="PopED") directory of the PopED installation.
Added a 2-compartment, oral absorption, multiple dose example to the system.file("examples", package="PopED") directory of the PopED installation.
Updated plot_efficiency_of_windows() to allow for the plotting of the RSE of each parameter on the y-axis.
Updated error handing for the Laplace approximation of the ED OFV.
Fixed bug when computing FIM with only one BSV term present in model (calculation gave an error).
Fixed a bug in plot_model_predictions where an error was returned if not all time values in the xt matrix were to be used for the design calculation (ni is different from size(xt,2), see ?create_poped_database).
Various small bug fixes.
Updated package author list
New functionality to compute the ED OFV using the Laplace approximation. This can be orders of magnitude faster than the standard MC integration approach. See '?ed_laplace_ofv' and '?evaluate.e.ofv.fim'
Added a general function to compute the FIM and OFV(FIM) for all avaialbale methods in PopED. See '?calc_ofv_and_fim'.
Added a general optimization algorithm 'RS_opt_gen()' that works for both D-family and E-family optimization.
Added optimization of E-family designs to 'poped_optimize()'.
Changed distribution tests for package building
Fixed bug where correlations between BSV (between subject variability) terms in the model gave an error when creating a PopED database
Fixed a bug where get_rse failed when a parameter had a value of 3.