NCA Calculations and Population Model Diagnosis

A flexible tool that can perform (i) traditional non-compartmental analysis (NCA) and (ii) Simulation-based posterior predictive checks for population pharmacokinetic (PK) and/or pharmacodynamic (PKPD) models using NCA metrics.


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A flexible tool that can perform:

  1. Traditional non-compartmental analysis (NCA) and
  2. Simulation-based posterior predictive checks for population pharmacokinetic (PK) and/or pharmacodynamic (PKPD) models using NCA metrics.

You need to have R installed. Download the latest version of R from www.r-project.org. Install ncappc in R using one of the following methods:

  • latest stable release -- From CRAN. Write at the R command line:
install.packages("ncappc")
  • Latest development version -- from Github. Note that the command below installs the "master" (development) branch; if you want the release branch from Github add ref="release" to the install_github() call. The install_github() approach requires that you build from source, i.e. make and compilers must be installed on your system -- see the R FAQ for your operating system; you may also need to install dependencies manually.
devtools::install_github("UUPharmacometrics/ncappc",build_vignettes=TRUE)

News

ncappc 0.3.0

  • New mean and variance of NCA metrics histogram plots

  • Updating how reports are generated and standardizing how they appear

  • Change how estimate_nca works, making tidy calculations the default and assuring that that the same function works for both real and simulated data

  • Added parallel computation of NCA metrics for simulated data

  • Added a number of automatic tests used for checking the package includung results from ncappc publication.

  • Added a NEWS.md file to track changes to the package.

  • Fixed depencies between ggplot2, grid and scales

  • Updated vignettes

  • More examples added to documentation

  • Allowing extrapolation for fewer than three points in the elimination phase of a profile

  • Allow timing messages to be turned on and off.

  • Bug fixes

  • linear-log option was changed to linearup-logdown

  • Central tendency measure for NCA metrics changed from mean to median

  • Updated documentation

  • Changed package maintainer

  • MRTINF pitfall fixed

  • Added continuous integration

  • Made onlyNCA work as it should

Reference manual

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install.packages("ncappc")

0.3.0 by Andrew C. Hooker, a year ago


Browse source code at https://github.com/cran/ncappc


Authors: Chayan Acharya [aut] , Andrew C. Hooker [aut, cre] , Gulbeyaz Y. Turkyilmaz [aut] , Siv Jonsson [aut] , Mats O. Karlsson [aut]


Documentation:   PDF Manual  


Task views: Analysis of Pharmacokinetic Data


GPL-3 license


Imports scales, gtable, knitr, xtable, reshape2, dplyr, Cairo, readr, lazyeval, PopED, magrittr, rlang, purrr, tibble, rmarkdown, tidyr, ggplot2, grid, gridExtra, grDevices, stats, bookdown

Suggests testthat


See at CRAN