A Virtual Patient Simulator in the Context of Calcium and Phosphate Homeostasis

Explore calcium (Ca) and phosphate (Pi) homeostasis with two novel 'Shiny' apps, building upon on a previously published mathematical model written in C, to ensure efficient computations. The underlying model is accessible here < https://pubmed.ncbi.nlm.nih.gov/28747359/)>. The first application explores the fundamentals of Ca-Pi homeostasis, while the second provides interactive case studies for in-depth exploration of the topic, thereby seeking to foster student engagement and an integrative understanding of Ca-Pi regulation.

CaPO4Sim, the Virtual Physiology Simulator

These apps were developed in the Interface Group.

Installation

install.packages("DivadNojnarg/CaPO4Sim")

Access Apps

library(CaPO4Sim)
# entry level app
run_CaPO4Sim(context = "introduction")
# virtual patient Bootstrap 4
run_CaPO4Sim(context = "virtual-patient")

Note that for the patient simulator, you need to install a compiler: either Rtools for windows or clang for Mac/Linux. If you don't want, you can still access these apps online.

Demonstration

Entry Level Application

Virtual Patient Simulator

Contacts

david.granjon_at_uzh.ch

Staff

• Project manager: Dr. Diane de Zélicourt, Prof. Vartan Kurtcuoglu and Dr. David Granjon
• Experts in Physiology:
  • Prof. François Verrey,
  • Prof. Olivier Bonny,
  • Prof. Bernard Rossier,
  • Prof. Carsten Wagner
• Graphic designer: Tara von Grebel and Dr. David Granjon
• Animation: Janine Meyer
• Model developer: Dr. David Granjon
• Web/R developer: Dr. David Granjon
• Server management: Dr. David Granjon

Acknowledgments

I thank RStudio for providing us with RStudio Connect licences. All illustration backgrounds were designed by Tara Von Grebel and animations were produced by Janine Meyer, both of the Multimedia and eLearning-Services, University of Zurich.