ToxCast Data Analysis Pipeline

The ToxCast Data Analysis Pipeline ('tcpl') is an R package that manages, curve-fits, plots, and stores ToxCast data to populate its linked MySQL database, 'invitrodb'. The package was developed for the chemical screening data curated by the US EPA's Toxicity Forecaster (ToxCast) program, but 'tcpl' can be used to support diverse chemical screening efforts.


tcpl: The ToxCast Data Analysis Pipeline Supporting Accessible Bioactivity Data for Toxicology

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Welcome to the GitHub repository for the tcpl package.

The ToxCast Data Analysis Pipeline (tcpl) is an R package that manages, curve-fits, plots, and stores ToxCast data to populate its linked MySQL database, invitrodb. The package was developed for the chemical screening data generated by the US EPA’s Toxicity Forecaster (ToxCast) program. tcpl can be used to support diverse chemical screening efforts.

If you are interested in contributing or want to report a bug, please submit a issue or start a discussion. See CONTRIBUTING for more information.

To install the current development version, run the following command:

devtools::install_github("USEPA/CompTox-ToxCast-tcpl")

Disclaimer

The United States Environmental Protection Agency (EPA) GitHub project code is provided on an “as is” basis and the user assumes responsibility for its use. EPA has relinquished control of the information and no longer has responsibility to protect the integrity, confidentiality, or availability of the information. Any reference to specific commercial products, processes, or services by service mark, trademark, manufacturer, or otherwise, does not constitute or imply their endorsement, recommendation or favoring by EPA. The EPA seal and logo shall not be used in any manner to imply endorsement of any commercial product or activity by EPA or the United States Government.

Reference manual

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install.packages("tcpl")

3.3.1 by Madison Feshuk, a year ago


https://github.com/USEPA/CompTox-ToxCast-tcpl, https://www.epa.gov/comptox-tools/toxicity-forecasting-toxcast


Report a bug at https://github.com/USEPA/CompTox-ToxCast-tcpl/issues


Browse source code at https://github.com/cran/tcpl


Authors: Dayne L Filer [aut] , Jason Brown [ctb] , Madison Feshuk [cre] , Carter Thunes [ctb] , Sarah E Davidson-Fritz [ctb] (ORCID: , Kelly Carstens [ctb] , Elizabeth Gilson [ctb] , Lindsay Knupp [ctb] , Lori Kolaczkowski [ctb] , Ashley Ko [ctb] , Zhihui Zhao [ctb] , Kurt Dunham [ctb] , Todd Zurlinden [ctb] , Parth Kothiya [ctb] , Woodrow R Setzer [ctb] , Matthew T Martin [ctb, ths] , Richard S Judson [ctb, ths] (ORCID: , Katie Paul Friedman [ctb] (ORCID:


Documentation:   PDF Manual  


MIT + file LICENSE license


Imports data.table, DBI, RMariaDB, numDeriv, RColorBrewer, utils, stats, methods, graphics, grDevices, sqldf, dplyr, tidyr, plotly, tcplfit2, ggplot2, gridExtra, stringr, rlang, ctxR, viridis, gt

Suggests roxygen2, knitr, prettydoc, rmarkdown, htmlTable, testthat, reshape2, kableExtra, colorspace, magrittr, vdiffr, httptest, rmdformats, gtable


Suggested by Rcurvep, tcplfit2, toxEval.


See at CRAN