Safety Diagnostics for Dose-Escalation Trial Designs

Enhances various R packages that support the design and simulation of phase 1 dose-escalation trials, adding diagnostics to examine the safety characteristics of these designs in light of expected inter-individual variation in pharmacokinetics and pharmacodynamics. See Norris (2020), "Retrospective analysis of a fatal dose-finding trial" .


Reference manual

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0.1-4 by David C. Norris, a month ago

Browse source code at

Authors: David C. Norris [aut, cre, cph]

Documentation:   PDF Manual  

MIT + file LICENSE license

Imports methods, dplyr, rlang, stringr, knitr, kableExtra

Depends on magrittr, escalation, data.table

Suggests rmarkdown, bookdown, tufte, testthat

See at CRAN