Safety Diagnostics for Dose-Escalation Trial Designs

Enhances various R packages that support the design and simulation of phase 1 dose-escalation trials, adding diagnostics to examine the safety characteristics of these designs in light of expected inter-individual variation in pharmacokinetics and pharmacodynamics. See Norris (2020), "Retrospective analysis of a fatal dose-finding trial" .


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install.packages("precautionary")

0.1-2 by David C. Norris, 9 days ago


https://precisionmethods.guru/


Browse source code at https://github.com/cran/precautionary


Authors: David C. Norris [aut, cre, cph]


Documentation:   PDF Manual  


MIT + file LICENSE license


Imports methods, dplyr, rlang, stringr, knitr, kableExtra

Depends on magrittr, escalation, data.table

Suggests rmarkdown, bookdown, tufte, testthat


See at CRAN