Modular Approach to Dose Finding Clinical Trials
Methods for working with dose-finding clinical trials. We provide
implementations of many dose-finding clinical trial designs, including the
continual reassessment method (CRM) by O'Quigley et al. (1990)
, the toxicity probability interval (TPI) design by Ji
et al. (2007) , the modified TPI (mTPI) design
by Ji et al. (2010) , the Bayesian optimal
interval design (BOIN) by Liu & Yuan (2015) , EffTox
by Thall & Cook (2004) ; the design of
Wages & Tait (2015) , and the 3+3
described by Korn et al. (1994) . All designs
are implemented with a common interface. We also offer optional additional
classes to tailor the behaviour of all designs, including avoiding skipping
doses, stopping after n patients have been treated at the recommended dose,
stopping when a toxicity condition is met, or demanding that n patients are
treated before stopping is allowed. By daisy-chaining together these classes
using the pipe operator from 'magrittr', it is simple to tailor the
behaviour of a dose-finding design so it behaves how the trialist wants.
Having provided a flexible interface for specifying designs, we then provide
functions to run simulations and calculate dose-paths for future cohorts of
patients.