Dose Transition Pathways for Continual Reassessment Method

Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) . DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.


Reference manual

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0.1.1 by Christina Yap, 4 months ago

Browse source code at

Authors: Christina Yap [aut, cre] , Daniel Slade [aut] , Kristian Brock [aut] , Yi Pan [aut]

Documentation:   PDF Manual  

GPL (>= 2) license

Imports diagram, dfcrm

Suggests knitr, rmarkdown, testthat

See at CRAN