Dose Transition Pathways for Continual Reassessment Method

Provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) . DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The 'dtpcrm' package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.


News

Reference manual

It appears you don't have a PDF plugin for this browser. You can click here to download the reference manual.

install.packages("dtpcrm")

0.1.1 by Christina Yap, 5 days ago


Browse source code at https://github.com/cran/dtpcrm


Authors: Christina Yap [aut, cre] , Daniel Slade [aut] , Kristian Brock [aut] , Yi Pan [aut]


Documentation:   PDF Manual  


GPL (>= 2) license


Imports diagram, dfcrm

Suggests knitr, rmarkdown, testthat


See at CRAN