Phase I Dose Escalation Study Design for Vaccines

A Bayesian Phase I cancer vaccine trial design is implemented in this package. The design allows simultaneous evaluation of safety and immunogenicity outcomes in the context of vaccine studies. See Wang (2019) for the details of the Phase I cancer vaccine trial design.


Reference manual

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2.1 by Chenguang Wang, a year ago

Browse source code at

Authors: Zilu Wang [aut, cre] Chenguang Wang [aut, cre] Gary L Rosner [aut] Richard BS Roden [aut] Trustees of Columbia University [cph] (tools/make_cpp.R , R/stanmodels.R)

Documentation:   PDF Manual  

GPL (>= 3) license

Imports sqldf, parallel

Depends on methods, rstan, Rcpp

Suggests knitr, shiny, rmarkdown, pander, xtable

Linking to BH, Rcpp, rstan, RcppEigen, StanHeaders

System requirements: GNU make

See at CRAN