Adaptive Optimal Two-Stage Designs in R

Optimize one or two-arm, two-stage designs for clinical trials with respect to several pre-implemented objective criteria or implement custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See and for details.


Reference manual

It appears you don't have a PDF plugin for this browser. You can click here to download the reference manual.


1.0.0 by Kevin Kunzmann, 7 months ago

Report a bug at

Browse source code at

Authors: Kevin Kunzmann [aut, cre] , Maximilian Pilz [aut]

Documentation:   PDF Manual  

MIT + file LICENSE license

Imports nloptr, methods, glue

Suggests knitr, rmarkdown, testthat, covr, rpact, vdiffr, pwr, dplyr, ggplot2, tidyr, gridExtra, bookdown

See at CRAN