Adaptive Optimal Two-Stage Designs

Optimize one or two-arm, two-stage designs for clinical trials with respect to several implemented objective criteria or custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz et al. (2019) and Kunzmann et al. (2021) for details.

adoptr

Adaptive optimal two-stage designs for clinical trials with one or two arms. For details on the core theoretical background, see:

Pilz M, Kunzmann K, Herrmann C, Rauch G, Kieser M. A variational approach to optimal two-stage designs. Statistics in Medicine. 2019;38(21):4159–4171. https://doi.org/10.1002/sim.8291

Installation

Install the latest CRAN release via

install.packages("adoptr")

and the development version directly from GitHub with:

devtools::install_github("optad/adoptr")

Documentation

The documentation is hosted at https://optad.github.io/adoptr.

Validation Report

We provide an extensive validation report for adoptr which is implemented using the bookdown package. The sources are available at https://github.com/optad/adoptr-validation-report and the last build version is hosted at https://optad.github.io/adoptr-validation-report.