Adaptive Optimal Two-Stage Designs in R

Optimize one or two-arm, two-stage designs for clinical trials with respect to several pre-implemented objective criteria or implement custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz M, Kunzmann K, Herrmann C, Rauch G, Kieser M. A variational approach to optimal two-stage designs. Statistics in Medicine. 2019;38(21):4159–4171. for details.


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0.4.2 by Kevin Kunzmann, 19 days ago

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Authors: Kevin Kunzmann [aut, cre] , Maximilian Pilz [aut]

Documentation:   PDF Manual  

MIT + file LICENSE license

Imports nloptr, methods, glue, stringr

Suggests knitr, rmarkdown, testthat, covr, rpact, vdiffr, pwr, dplyr, ggplot2, tidyr, gridExtra, bookdown

See at CRAN