Optimize one or two-arm, two-stage designs for clinical trials with
respect to several pre-implemented objective criteria or implement custom
Optimization under uncertainty and conditional (given stage-one outcome)
constraints are supported.
See Pilz M, Kunzmann K, Herrmann C, Rauch G, Kieser M. A variational
approach to optimal two-stage designs. Statistics in Medicine. 2019;38(21):4159–4171.