Confirmatory Adaptive Clinical Trial Design and Analysis

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) . This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.


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rpact 1.0.0

  • First release of rpact

Reference manual

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install.packages("rpact")

1.0.0 by Friedrich Pahlke, 5 months ago


https://www.rpact.org


Report a bug at https://bugreport.rpact.org


Browse source code at https://github.com/cran/rpact


Authors: Gernot Wassmer [aut] , Friedrich Pahlke [aut, cre]


Documentation:   PDF Manual  


GPL-3 license


Imports methods, stats, utils, graphics

Suggests parallel, ggplot2, testthat


See at CRAN