Confirmatory Adaptive Clinical Trial Design and Analysis

Design and analysis of confirmatory adaptive clinical trials with continuous, binary, and survival endpoints according to the methods described in the monograph by Wassmer and Brannath (2016) . This includes classical group sequential as well as multi-stage adaptive hypotheses tests that are based on the combination testing principle.


rpact 1.0.0

  • First release of rpact

Reference manual

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3.2.1 by Friedrich Pahlke, 23 days ago

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Authors: Gernot Wassmer [aut] , Friedrich Pahlke [aut, cre]

Documentation:   PDF Manual  

Task views: Clinical Trial Design, Monitoring, and Analysis

LGPL-3 license

Imports methods, stats, utils, graphics, tools, Rcpp

Suggests parallel, ggplot2, testthat, mnormt, knitr, rmarkdown

Linking to Rcpp

Suggested by adoptr, eventTrack, lrstat.

See at CRAN