Planning and Analyzing Dose Finding Experiments

The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) ).


Reference manual

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1.0-2 by Bjoern Bornkamp, 16 days ago

Browse source code at

Authors: Bjoern Bornkamp [aut, cre] , Jose Pinheiro [aut] , Frank Bretz [aut] , Ludger Sandig [aut]

Documentation:   PDF Manual  

Task views: Clinical Trial Design, Monitoring, and Analysis, Design of Experiments (DoE) & Analysis of Experimental Data

GPL-3 license

Depends on lattice, mvtnorm

Suggests numDeriv, Rsolnp, quadprog, parallel, multcomp, ggplot2, knitr, rmarkdown, MASS, testthat

Imported by LRcontrast, clinDR, clustDRM, dosedesignR, uniReg.

Depended on by MCPModGeneral, TestingSimilarity.

Suggested by MCPModPack.

See at CRAN