Functions for Optimal Matching

Distance based bipartite matching using minimum cost flow, oriented to matching of treatment and control groups in observational studies ('Hansen' and 'Klopfer' 2006 ). Routines are provided to generate distances from generalised linear models (propensity score matching), formulas giving variables on which to limit matched distances, stratified or exact matching directives, or calipers, alone or in combination.

"Hit and Run" and "Shake and Bake" for Sampling Uniformly from Convex Shapes

The "Hit and Run" Markov Chain Monte Carlo method for sampling uniformly from convex shapes defined by linear constraints, and the "Shake and Bake" method for sampling from the boundary of such shapes. Includes specialized functions for sampling normalized weights with arbitrary linear constraints. Tervonen, T., van Valkenhoef, G., Basturk, N., and Postmus, D. (2012) . van Valkenhoef, G., Tervonen, T., and Postmus, D. (2014) .

Various Functions to Facilitate Visualization of Data and Analysis

When analyzing data, plots are a helpful tool for visualizing data and interpreting statistical models. This package provides a set of simple tools for building plots incrementally, starting with an empty plot region, and adding bars, data points, regression lines, error bars, gradient legends, density distributions in the margins, and even pictures. The package builds further on R graphics by simply combining functions and settings in order to reduce the amount of code to produce for the user. As a result, the package does not use formula input or special syntax, but can be used in combination with default R plot functions. Note: Most of the functions were part of the package 'itsadug', which is now split in two packages: 1. the package 'itsadug', which contains the core functions for visualizing and evaluating nonlinear regression models, and 2. the package 'plotfunctions', which contains more general plot functions.

Classification and Regression Tests

Provides wrapper functions for running classification and regression tests using different machine learning techniques, such as Random Forests and decision trees. The package provides standardized methods for preparing data to suit the algorithm's needs, training a model, making predictions, and evaluating results. Also, some functions are provided to run multiple instances of a test.

Highly Adaptive Lasso Conditional Density Estimation

An algorithm for flexible conditional density estimation based on application of pooled hazard regression to an artificial repeated measures dataset constructed by discretizing the support of the outcome variable. To facilitate non/semi-parametric estimation of the conditional density, the highly adaptive lasso, a nonparametric regression function shown to reliably estimate a large class of functions at a fast convergence rate, is utilized. The pooled hazards data augmentation formulation implemented was first described by Díaz and van der Laan (2011) . To complement the conditional density estimation utilities, tools for efficient nonparametric inverse probability weighted (IPW) estimation of the causal effects of stochastic shift interventions (modified treatment policies), directly utilizing the density estimation technique for construction of the generalized propensity score, are provided. These IPW estimators utilize undersmoothing (sieve estimation) of the conditional density estimators in order to achieve the non/semi-parametric efficiency bound.

Minimization Methods for Ill-Conditioned Problems

Implementation of methods for minimizing ill-conditioned problems. Currently only includes regularized (quasi-)newton optimization (Kanzow and Steck et al. (2023), ).

Gene Cluster Visualizations

Provides tools for plotting gene clusters and transcripts by importing data from GenBank, FASTA, and GFF files. It performs BLASTP and MUMmer alignments [Altschul et al. (1990) ; Delcher et al. (1999) ] and displays results on gene arrow maps. Extensive customization options are available, including legends, labels, annotations, scales, colors, tooltips, and more.

'shiny' Cron Expression Input Widget

A widget for 'shiny' apps to handle schedule expression input, using the 'cron-expression-input' JavaScript component. Note that this does not edit the 'crontab' file, it is just an input element for the schedules. See < https://github.com/DatalabFabriek/shinycroneditor/blob/main/inst/examples/shiny-app.R> for an example implementation.

Predictive Power Score

The Predictive Power Score (PPS) is an asymmetric, data-type-agnostic score that can detect linear or non-linear relationships between two variables. The score ranges from 0 (no predictive power) to 1 (perfect predictive power). PPS can be useful for data exploration purposes, in the same way correlation analysis is. For more information on PPS, see < https://github.com/paulvanderlaken/ppsr>.

Relative Distribution Methods

Tools for the comparison of distributions. This includes nonparametric estimation of the relative distribution PDF and CDF and numerical summaries as described in "Relative Distribution Methods in the Social Sciences" by Mark S. Handcock and Martina Morris, Springer-Verlag, 1999, Springer-Verlag, ISBN 0387987789.