Planning and Analysing Survival Studies under Non-Proportional Hazards

Piecewise constant hazard functions are used to flexibly model survival distributions with non-proportional hazards and to simulate data from the specified distributions. Also, a function to calculate weighted log-rank tests for the comparison of two hazard functions is included. Finally, a function to calculate a test using the maximum of a set of test statistics from weighted log-rank tests is provided. This test utilizes the asymptotic multivariate normal joint distribution of the separate test statistics. The correlation is estimated from the data.


Reference manual

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2.0 by Robin Ristl, a year ago

Browse source code at

Authors: Robin Ristl [aut, cre] , Nicolas Ballarini [ctb]

Documentation:   PDF Manual  

GPL-3 license

Imports stats, graphics, mvtnorm, ggplot2

Suggests knitr, shiny, shinycssloaders, formatR, styler, rmarkdown

See at CRAN