Statistical Framework for in Vivo Drug Combination Studies

A framework for evaluating drug combination effects in preclinical in vivo studies. 'SynergyLMM' provides functions to analyze longitudinal tumor growth experiments using mixed-effects models, perform time-resolved analyses of synergy and antagonism, evaluate model diagnostics and performance, and assess both post-hoc and a priori statistical power. The calculation of drug combination synergy follows the statistical framework provided by Demidenko and Miller (2019, ). The implementation and analysis of linear mixed-effect models is based on the methods described by Pinheiro and Bates (2000, ), and Gałecki and Burzykowski (2013, ).