Construct PGx PRS

Construct pharmacogenomics (PGx) polygenic risk score (PRS) with PRS-PGx-Unadj (unadjusted), PRS-PGx-CT (clumping and thresholding), PRS-PGx-L, -GL, -SGL (penalized regression), PRS-PGx-Bayes (Bayesian regression). Package is based on ''Pharmacogenomics Polyenic Risk Score for Drug Response Prediction Using PRS-PGx Methods'' by Zhai, S., Zhang, H., Mehrotra, D.V., and Shen, J., 2021 (submitted).


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install.packages("PRSPGx")

0.1.0 by Song Zhai, a month ago


Browse source code at https://github.com/cran/PRSPGx


Authors: Song Zhai [aut, cre]


Documentation:   PDF Manual  


GPL (>= 2) license


Imports gglasso, SGL, glmnet, bigsnpr, Matrix, GIGrvg, MCMCpack, bdsmatrix, bigsparser, lmtest, mvtnorm, propagate, bigparallelr, methods, bigstatsr

Suggests knitr, rmarkdown


See at CRAN