Construct PGx PRS

Construct pharmacogenomics (PGx) polygenic risk score (PRS) with PRS-PGx-Unadj (unadjusted), PRS-PGx-CT (clumping and thresholding), PRS-PGx-L, -GL, -SGL (penalized regression), PRS-PGx-Bayes (Bayesian regression). Package is based on ''Pharmacogenomics Polyenic Risk Score for Drug Response Prediction Using PRS-PGx Methods'' by Zhai, S., Zhang, H., Mehrotra, D.V., and Shen, J., 2021 (submitted).


Reference manual

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0.1.0 by Song Zhai, a month ago

Browse source code at

Authors: Song Zhai [aut, cre]

Documentation:   PDF Manual  

GPL (>= 2) license

Imports gglasso, SGL, glmnet, bigsnpr, Matrix, GIGrvg, MCMCpack, bdsmatrix, bigsparser, lmtest, mvtnorm, propagate, bigparallelr, methods, bigstatsr

Suggests knitr, rmarkdown

See at CRAN