Implements novel nonparametric approaches to address
biases and confounding when comparing treatments or exposures in
observational studies of outcomes. While designed and appropriate for use
in studies involving medicine and the life sciences, the package can be
used in other situations involving outcomes with multiple confounders.
The package implements a family of methods for non-parametric bias correction
when comparing treatments in observational studies, including survival
analysis settings, where competing risks and/or censoring may be present.
The approach extends to bias-corrected personalized predictions of treatment
outcome differences, and analysis of heterogeneity of treatment effect-sizes
across patient subgroups. For further details, please see:
Lauve NR, Nelson SJ, Young SS, Obenchain RL, Lambert CG. LocalControl:
An R Package for Comparative Safety and Effectiveness Research.
Journal of Statistical Software. 2020. p. 1–32. Available from
LocalControl is an R package implementing novel nonparametric approaches to address biases and confounding when comparing treatments or exposures in observational studies of outcomes.
See R help pages for examples on how to run each of the package functions.
LocalControl is licensed under Apache License 2.0
Stable? (Let people know what their expectations should be)
Deprecated the localControlCompetingRisks(), localControlNearestNeighbors(), and (hidden) doLocalControl() functions.
Added a new function in their place, LocalControl().
The behavior of the three removed functions now exists in this function.
The new “outcomeType” parameter allows users to toggle between the competingRisks and NearestNeighbors functionality.
Deprecated the plotLocalControlCIF and plotLocalControlLTD functions, replaced with s3 (plot()) functions.
Added S3 functions: print() and summary() have also been added for the LocalControl classes.
Changed the structure of the LocalControlCS and LocalControlCR objects.
Removed the summary object.
The summary is now created upon request using the summary() s3 function with the LocalControl classes.
Added a formula interface for LocalControl (beta).
LocalControl(data = lindner, modelForm = formula('cardbill ~ abcix | stent + female + acutemi'))
Is now a valid alternative to:
LocalControl( data = lindner, clusterVars = c("stent", "female", "acutemi"), treatmentColName = "abcix", outcomeColName = "cardbill")