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Prototype of Multiple Latent Dirichlet Allocation Runs
Determine a Prototype from a number of runs of Latent Dirichlet Allocation (LDA) measuring its similarities with S-CLOP: A procedure to select the LDA run with highest mean pairwise similarity, which is measured by S-CLOP (Similarity of multiple sets by Clustering with Local Pruning), to all other runs. LDA runs are specified by its assignments leading to estimators for distribution parameters. Repeated runs lead to different results, which we encounter by choosing the most representative LDA run as prototype.
Conditional Minimax Regret Design Rules
Implements Conditional Minimax Regret design rules for
pilot-informed experimental assignment, as proposed in Yamin (2026)
Simultaneous Analysis of Multiplexed Metabarcodes
A comprehensive set of wrapper functions for the analysis of multiplex metabarcode data. It includes robust wrappers for 'Cutadapt' and 'DADA2' to trim primers, filter reads, perform amplicon sequence variant (ASV) inference, and assign taxonomy. The package can handle single metabarcode datasets, datasets with two pooled metabarcodes, or multiple datasets simultaneously. The final output is a matrix per metabarcode, containing both ASV abundance data and associated taxonomic assignments. An optional function converts these matrices into 'phyloseq' and 'taxmap' objects. For more information on 'DADA2', including information on how DADA2 infers samples sequences, see Callahan et al. (2016)
Finder of Rare Entities (FiRE)
The algorithm assigns rareness/ outlierness score to every sample in voluminous datasets.
The algorithm makes multiple estimations of the proximity between a pair of samples, in low-dimensional spaces. To compute proximity, FiRE uses Sketching, a variant of locality sensitive hashing. For more details: Jindal, A., Gupta, P., Jayadeva and Sengupta, D., 2018. Discovery of rare cells from voluminous single cell expression data. Nature Communications, 9(1), p.4719.
Spatial Generalised Linear Mixed Models for Areal Unit Data
Implements a class of univariate and multivariate spatial generalised linear mixed models for areal unit data, with inference in a Bayesian setting using Markov chain Monte Carlo (MCMC) simulation using a single or multiple Markov chains. The response variable can be binomial, Gaussian, multinomial, Poisson or zero-inflated Poisson (ZIP), and spatial autocorrelation is modelled by a set of random effects that are assigned a conditional autoregressive (CAR) prior distribution. A number of different models are available for univariate spatial data, including models with no random effects as well as random effects modelled by different types of CAR prior, including the BYM model (Besag et al., 1991,
Optimal Pairing and Matching via Linear Assignment
Solves optimal pairing and matching problems using linear assignment
algorithms. Provides implementations of the Hungarian method (Kuhn 1955)
Multiple Precision Arithmetic
Multiple Precision Arithmetic (big integers and rationals, prime number tests, matrix computation), "arithmetic without limitations" using the C library GMP (GNU Multiple Precision Arithmetic).
Multiple Fill and Colour Scales in 'ggplot2'
Use multiple fill and colour scales in 'ggplot2'.
Assign Treatments, Power Calculations, Balances, Impact Evaluation of Experiments
Assists in the whole process of designing and evaluating Randomized Control Trials.
Robust treatment assignment by strata/blocks, that handles misfits;
Power calculations of the minimum detectable treatment effect or minimum populations;
Balance tables of T-test of covariates;
Balance Regression: (treatment ~ all x variables) with F-test of null model;
Impact_evaluation: Impact evaluation regressions. This function
gives you the option to include control_vars, fixed effect variables,
cluster variables (for robust SE), multiple endogenous variables and
multiple heterogeneous variables (to test treatment effect heterogeneity)
summary_statistics: Function that creates a summary statistics table with statistics
rank observations in n groups: Creates a factor variable with n groups. Each group has
a min and max label attach to each category.
Athey, Susan, and Guido W. Imbens (2017)
Detecting Influence Paths with Information Theory
Traces information spread through interactions between features, utilising information theory measures and a higher-order generalisation of the concept of widest paths in graphs. In particular, 'vistla' can be used to better understand the results of high-throughput biomedical experiments, by organising the effects of the investigated intervention in a tree-like hierarchy from direct to indirect ones, following the plausible information relay circuits. Due to its higher-order nature, 'vistla' can handle multi-modality and assign multiple roles to a single feature.