Log-Likelihood Functions for 'rxode2'

Provides the log-likelihoods with gradients from 'stan' (Carpenter et al (2015), ) needed for generalized log-likelihood estimation in 'nlmixr2' (Fidler et al (2019) ). This is split of to reduce computational burden of recompiling 'rxode2' (Wang, Hallow and James (2016) ) which runs the 'nlmixr2' models during estimation.

rxode2ll

The goal of rxode2ll is to create log-likelihood functions for use in ‘rxode2’ and ‘nlmixr2’

Installation

You can install the development version of rxode2ll from GitHub with:

# install.packages("devtools")
devtools::install_github("nlmixr2/rxode2ll")

Examples

Each of the C++ interface to the stan log-likelihood equations can be used in a stand-alone manner. For example:

llikNorm(seq(-2,2,length.out=10), full=TRUE)

The following log-likelihood distributions are supported:

• llikNorm()
• llikPois()
• llikBinom()
• llikNbinom()
• llikNbinomMu()
• llikBeta()
• llikT()
• llikChisq()
• llikExp()
• llikF()
• llikGeom()
• llikUnif()
• llikWeibull()
• llikGamma()
• llikCauchy()