Analysis of DNA mixtures involving relatives by computation of likelihood ratios that account for dropout and drop-in, mutations, silent alleles and population
substructure. This is useful in kinship cases, like non-invasive prenatal paternity testing, where deductions about individuals' relationships rely on DNA mixtures,
and in criminal cases where the contributors to a mixed DNA stain may be related. Relationships are represented
by pedigrees and can include kinship between more than two individuals. The main function is relMix() and its graphical user interface relMixGUI().
The implementation and method is described in Dorum et al. (2017)
relMix makes relationship inference involving DNA mixtures with unknown
profiles and interprets DNA mixtures with related contributors. The main
function is the graphical user interface relMixGUI. A tutorial can be
found here: https://gdorum.github.io/relMix/articles/relMix.html
Install from CRAN as follows:
install.packages("relMix")
Alternatively, install the latest development version from GitHub:
# First install devtools if needed
if(!require(devtools)) install.packages("devtools")
#Install relMix from GitHub:
devtools::install_github("gdorum/relMix")
To provide pedigree plots, relMix uses the package tkrplot. However,
this package has some compatibility issues with MacOS and hence is not
included as a hard dependency. Users who wish to see pedigree plots in
the results screen have to install the package tkrplot manually with
install.packages("tkrplot")
The tkrplot package will be loaded by relMix automatially, so users do
not need to run library("tkrplot") in advance.