Nonlinear Mixed Effects Models in Population PK/PD, Estimation Routines

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 ).

Reference manual

install.packages("nlmixr2est")

7.2.1 by Matthew Fidler, 3 days ago

https://github.com/nlmixr2/nlmixr2est, https://nlmixr2.github.io/nlmixr2est/

Browse source code at https://github.com/cran/nlmixr2est

Authors: Matthew Fidler [aut, cre] (ORCID: , Wenping Wang [aut] , Audrey Lavenu [ctb] , Ben Goodrich [ctb] , David Ardia [cph] , Dirk Eddelbuettel [cph] , Elizabeth Eskow [ctb] , Emmanuelle Comets [ctb] , Hadley Wickham [ctb] , Hajar Besbassi [ctb] , Hidde van de Beek [ctb] , Johannes Pfeifer [ctb] , Justin Wilkins [aut] , Katharine Mullen [cph] , Mahmoud Abdelwahab [ctb] , Marc Lavielle [ctb] , Mason McComb [ctb] , Mirjam Trame [ctb] , Richard Hooijmaijers [aut] , Rik Schoemaker [aut] , Robert B. Schnabel [ctb] , Robert Leary [ctb] , Teun Post [ctb] , Vipul Mann [aut] , Yuan Xiong [aut]

Documentation: PDF Manual

GPL (>= 3) license

Imports backports, checkmate, cli, graphics, knitr, L0Learn, lbfgsb3c, lotri, methods, minqa, n1qn1, nlme, Rcpp, RcppTrust, rex, rxode2, stats, symengine, utils