Nonlinear Mixed Effects Models in Population PK/PD, Data

Datasets for 'nlmixr2' and 'rxode2'. 'nlmixr2' is used for fitting and comparing nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 ). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 ).

nlmixr2data

The goal of nlmixr2data is to include all the example datasets from the nlmixr2 project in one place.

Example

This shows the theo_sd dataset, the hello world for nlmixr2.

library(nlmixr2data)
head(theo_sd)
#>   ID TIME    DV     AMT EVID CMT   WT
#> 1  1 0.00  0.00 319.992  101   1 79.6
#> 2  1 0.00  0.74   0.000    0   2 79.6
#> 3  1 0.25  2.84   0.000    0   2 79.6
#> 4  1 0.57  6.57   0.000    0   2 79.6
#> 5  1 1.12 10.50   0.000    0   2 79.6
#> 6  1 2.02  9.66   0.000    0   2 79.6

Installation

You can install the development version of nlmixr2data from GitHub with:

# install.packages("remotes")
remotes::install_github("nlmixr2/nlmixr2data")