Drug Interaction Modeling Based on Loewe Additivity Following Harbron's Approach

Perform assessment of synergy/antagonism for drug combinations based on the Loewe additivity model, following Harbron's approach (Statistics in Medicine, 2010, ). The package allows flexible modeling of the drug interaction index and supports "2-stage" estimation in addition to "1-stage" estimation, including bootstrap-based confidence intervals. The method requires data on the monotherapy responses and the package accommodates both checkerboard and ray designs. Functions are available for graphical exploration of model goodness-of-fit and diagnostics, as well as for synergy/antagonism assessment in 2D and 3D.


1.0.2 (2018-06-15) o reduce run time for tests and vignette compilation 1.0.1 (2018-06-14) o fixes for tau plot comparison, including compatibility with the upcoming version of ggplot2 1.0.0 (2018-05-09) o initial public release

Reference manual

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1.1.1 by Maxim Nazarov, a year ago

Browse source code at https://github.com/cran/drugCombo

Authors: Maxim Nazarov , Nele Goeyvaerts , Chris Harbron (original article and code)

Documentation:   PDF Manual  

GPL-3 license

Imports ggplot2, minpack.lm, BIGL, rgl, nlme, Deriv, methods, stats

Suggests knitr, rmarkdown, testthat, Cairo

See at CRAN