Patient Subgroup Identification for Clinical Drug Development

Function Wrapper contains four algorithms for developing threshold-based multivariate (prognostic/predictive) biomarker signatures via bootstrapping and aggregating of thresholds from trees, Monte-Carlo variations of the Adaptive Indexing method and Patient Rule Induction Method. Variable selection is automatically built-in to these algorithms. Final signatures are returned with interaction plots for predictive signatures. Cross-validation performance evaluation and testing dataset results are also output.


Wishlist (formerly TODO):

  • To include optAUC package as another candidate methods

======================================================================== Changes in 0.10:

  • first deposite to CRAN
  • add citation

Reference manual

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0.11 by Xin Huang, 3 years ago

Browse source code at

Authors: Xin Huang , Yan Sun , Saptarshi Chatterjee and Paul Trow

Documentation:   PDF Manual  

GPL-3 license

Imports rpart, stats, glmnet

Depends on AIM, survival, ggplot2, Matrix

See at CRAN