Seamless Adaptive Multi-Arm Multi-Stage Enrichment

Design a Bayesian seamless multi-arm biomarker-enriched phase II/III design with the survival endpoint with allowing sample size re-estimation. James M S Wason, Jean E Abraham, Richard D Baird, Ioannis Gournaris, Anne-Laure Vallier, James D Brenton, Helena M Earl, Adrian P Mander (2015) . Guosheng Yin, Nan Chen, J. Jack Lee (2018) . Ying Yuan, Beibei Guo, Mark Munsell, Karen Lu, Amir Jazaeri (2016) .