Tools for Normalizing and Comparing ChIP-seq Samples

Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the premier technology for profiling genome-wide localization of chromatin-binding proteins, including transcription factors and histones with various modifications. This package provides a robust method for normalizing ChIP-seq signals across individual samples or groups of samples. It also designs a self-contained system of statistical models for calling differential ChIP-seq signals between two or more biological conditions as well as for calling hypervariable ChIP-seq signals across samples. Refer to Tu et al. (2021) and Chen et al. (2021) for associated statistical details.


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install.packages("MAnorm2")

1.2.0 by Shiqi Tu, 15 days ago


https://github.com/tushiqi/MAnorm2


Report a bug at https://github.com/tushiqi/MAnorm2/issues


Browse source code at https://github.com/cran/MAnorm2


Authors: Shiqi Tu [aut, cre]


Documentation:   PDF Manual  


GPL-3 license


Imports stats, graphics, methods, locfit, scales, statmod

Suggests gplots, DescTools, knitr, rmarkdown


See at CRAN