Tools for Normalizing and Comparing ChIP-seq Samples

Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the premier technology for profiling genome-wide localization of chromatin-binding proteins, including transcription factors and histones with various modifications. This package provides a robust method for normalizing ChIP-seq signals across individual samples or groups of samples. It also designs a self-contained system of statistical models for calling differential ChIP-seq signals between two or more biological conditions as well as for calling hypervariable ChIP-seq signals across samples. Refer to Tu et al. (2021) and Chen et al. (2021) for associated statistical details.


Reference manual

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1.2.0 by Shiqi Tu, 5 months ago

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Authors: Shiqi Tu [aut, cre]

Documentation:   PDF Manual  

GPL-3 license

Imports stats, graphics, methods, locfit, scales, statmod

Suggests gplots, DescTools, knitr, rmarkdown

See at CRAN