Multiple, Unpacking, and Destructuring Assignment

Provides a %<-% operator to perform multiple, unpacking, and destructuring assignment in R. The operator unpacks the right-hand side of an assignment into multiple values and assigns these values to variables on the left-hand side of the assignment.

Sequential Multiple Assignment Randomized Trial Design

SMART trial design, as described by He, J., McClish, D., Sabo, R. (2021) , includes multiple stages of randomization, where participants are randomized to an initial treatment in the first stage and then subsequently re-randomized between treatments in the following stage.

Sequential Multiple Assignment Randomized Trials Design and Analyses

Implements the interim augmented inverse probability weighted estimator (IAIPWE) for estimating the value of treatment regimes embedded in sequential multiple assignment randomized trials (SMARTs). The IAIPWE subsumes both the inverse probability weighted estimator (IPWE) and the augmented inverse probability weighted estimator (AIPWE), enabling inference at interim and final analyses. The package provides functions for value estimation, sandwich variance computation, group sequential stopping boundaries, and sample size determination for multi-stage SMARTs with up to two treatment options at each stage. See Manschot, Laber, and Davidian (2023) for additional details.

Sequential Multiple Assignment Randomized Trial and Adaptive Randomization

Primary data analysis for sequential multiple assignment randomization trial (SMART) and calibration tools for clinical trial planning purposes. \n The methods used for this package include: \n (1) Likelihood-based global test (hypothesis test, power calculation) by in Zhong X., Cheng, B., Qian M., Cheung Y.K. (2019) . \n (2) IPWE-based global test (hypotehsis test, power calculation) by Ogbagaber S.B., Karp J., Wahed A.S. (2016) . \n (3) G estimates (pairwise comparison, power calculation) by Lavori R., Dawson P.W. (2012) . \n (4) IPW estimates (pairwise comparison, power calculation) by Murphy S.A. (2005) . \n (5) SAMRT with adaptive randomization by Cheung Y.K. (2015) .

Small N Sequential Multiple Assignment Randomized Trial Methods

Consolidated data simulation, sample size calculation and analysis functions for several snSMART (small sample sequential, multiple assignment, randomized trial) designs under one library. See Wei, B., Braun, T.M., Tamura, R.N. and Kidwell, K.M. "A Bayesian analysis of small n sequential multiple assignment randomized trials (snSMARTs)." (2018) Statistics in medicine, 37(26), pp.3723-3732 .

Wrap R Tools for Debugging and Parametric Programming

Tools for writing and debugging R code. Provides: '%.>%' dot-pipe (an 'S3' configurable pipe), unpack/to (R style multiple assignment/return), 'build_frame()'/'draw_frame()' ('data.frame' example tools), 'qc()' (quoting concatenate), ':=' (named map builder), 'let()' (converts non-standard evaluation interfaces to parametric standard evaluation interfaces, inspired by 'gtools::strmacro()' and 'base::bquote()'), and more.

Implementation of the minMSE Treatment Assignment Method for One or Multiple Treatment Groups

Performs treatment assignment for (field) experiments considering available, possibly multivariate and continuous, information (covariates, observable characteristics), that is: forms balanced treatment groups, according to the minMSE-method as proposed by Schneider and Schlather (2017) .

Power Analysis for a SMART Design

A set of tools for determining the necessary sample size in order to identify the optimal dynamic treatment regime in a sequential, multiple assignment, randomized trial (SMART). Utilizes multiple comparisons with the best methodology to adjust for multiple comparisons. Designed for an arbitrary SMART design. Please see Artman (2018) for more details.

Regression Discontinuity Design Application

Estimation of both single- and multiple-assignment Regression Discontinuity Designs (RDDs). Provides both parametric (global) and non-parametric (local) estimation choices for both sharp and fuzzy designs, along with power analysis and assumption checks. Introductions to the underlying logic and analysis of RDDs are in Thistlethwaite, D. L., Campbell, D. T. (1960) and Lee, D. S., Lemieux, T. (2010) .

Sample Size for SMART Designs in Non-Surgical Periodontal Trials

Sample size calculation to detect dynamic treatment regime (DTR) effects based on change in clinical attachment level (CAL) outcomes from a non-surgical chronic periodontitis treatments study. The experiment is performed under a Sequential Multiple Assignment Randomized Trial (SMART) design. The clustered tooth (sub-unit) level CAL outcomes are skewed, spatially-referenced, and non-randomly missing. The implemented algorithm is available in Xu et al. (2019+) .