Epigenome-Wide Mediation Analysis Study

DNA methylation is essential for human, and environment can change the DNA methylation and affect body status. Epigenome-Wide Mediation Analysis Study (EMAS) can find potential mediator CpG sites between exposure (x) and outcome (y) in epigenome-wide. For more information on the methods we used, please see the following references: Tingley, D. (2014) , Turner, S. D. (2018) , Rosseel, D. (2012) .

Waiting List Metrics Using Queuing Theory

Waiting list management using queuing theory to analyse, predict and manage queues, based on the approach described in Fong et al. (2022) . Aimed at UK National Health Service (NHS) applications, waiting list summary statistics, target-value calculations, waiting list simulation, and scheduling functions are included.

Draw XmR Charts for NHS 'Making Data Count' Programme

Provides tools for drawing Statistical Process Control (SPC) charts. This package supports the NHS 'Making Data Count' programme, and allows users to draw XmR charts, use change points and apply rules with summary indicators for when rules are breached.

Compare Two Data Frames and Summarise the Difference

Easy comparison of two tabular data objects in R. Specifically designed to show differences between two sets of data in a useful way that should make it easier to understand the differences, and if necessary, help you work out how to remedy them. Aims to offer a more useful output than all.equal() when your two data sets do not match, but isn't intended to replace all.equal() as a way to test for equality.

Species Sensitivity Distributions

Species sensitivity distributions are cumulative probability distributions which are fitted to toxicity concentrations for different species as described by Posthuma et al. (2001) . The ssdtools package uses Maximum Likelihood to fit distributions such as the gamma, log-logistic, log-normal and log-normal log-normal mixture. Multiple distributions can be averaged using Akaike Information Criteria. Confidence intervals on hazard concentrations and proportions are produced by bootstrapping.

Geometrical Functionality of the 'spatstat' Family

Defines spatial data types and supports geometrical operations on them. Data types include point patterns, windows (domains), pixel images, line segment patterns, tessellations and hyperframes. Capabilities include creation and manipulation of data (using command line or graphical interaction), plotting, geometrical operations (rotation, shift, rescale, affine transformation), convex hull, discretisation and pixellation, Dirichlet tessellation, Delaunay triangulation, pairwise distances, nearest-neighbour distances, distance transform, morphological operations (erosion, dilation, closing, opening), quadrat counting, geometrical measurement, geometrical covariance, colour maps, calculus on spatial domains, Gaussian blur, level sets of images, transects of images, intersections between objects, minimum distance matching. (Excludes spatial data on a network, which are supported by the package 'spatstat.linnet'.)

Data Visualisation Functions for Epidemiological Data Science Products

Tools for making epidemiological reporting easier with consistent static and dynamic charts and maps. Builds on 'ggplot2' for static visualizations as described in Wickham (2016) and 'plotly' for interactive visualizations as described in Sievert (2020) .

Temporal Parametric Hazard Modeling

Provides native R implementations of the multiphase parametric hazard model of Blackstone, Naftel, and Turner (1986) with a focus on behavioral parity, transparent numerics, and reproducible validation against reference outputs from the original 'C'/'SAS' HAZARD program, originally developed at the University of Alabama at Birmingham (UAB). The 'SAS'/'C' code and this R package are currently developed and maintained at The Cleveland Clinic Foundation, and the R code was wholly developed at The Cleveland Clinic Foundation. The generalized temporal decomposition family extends to longitudinal mixed-effects settings (Rajeswaran et al. 2018 ). The package is intentionally implemented in pure R first; performance-critical paths may later be accelerated with 'Rcpp' without changing the public interface.

Random Generation Functionality for the 'spatstat' Family

Functionality for random generation of spatial data in the 'spatstat' family of packages. Generates random spatial patterns of points according to many simple rules (complete spatial randomness, Poisson, binomial, random grid, systematic, cell), randomised alteration of patterns (thinning, random shift, jittering), simulated realisations of random point processes including simple sequential inhibition, Matern inhibition models, Neyman-Scott cluster processes (using direct, Brix-Kendall, or hybrid algorithms), log-Gaussian Cox processes, product shot noise cluster processes and Gibbs point processes (using Metropolis-Hastings birth-death-shift algorithm, alternating Gibbs sampler, or coupling-from-the-past perfect simulation). Also generates random spatial patterns of line segments, random tessellations, and random images (random noise, random mosaics). Excludes random generation on a linear network, which is covered by the separate package 'spatstat.linnet'.

R Fortunes

A collection of fortunes from the R community.