Power Analysis and Sample Size Calculation

Power analysis and sample size calculation for Welch and Hsu (Hedderich and Sachs (2018), ISBN:978-3-662-56657-2) t-tests including Monte-Carlo simulations of empirical power and type-I-error. Power and sample size calculation for Wilcoxon rank sum and signed rank tests via Monte-Carlo simulations. Power and sample size required for the evaluation of a diagnostic test(-system) (Flahault et al. (2005), ; Dobbin and Simon (2007), ) as well as for a single proportion (Fleiss et al. (2003), ISBN:978-0-471-52629-2; Piegorsch (2004), ; Thulin (2014), ), comparing two negative binomial rates (Zhu and Lakkis (2014), ), ANCOVA (Shieh (2020), ), reference ranges (Jennen-Steinmetz and Wellek (2005), ), multiple primary endpoints (Sozu et al. (2015), ISBN:978-3-319-22005-5), and AUC (Hanley and McNeil (1982), ).

Omics Data Analysis

Similarity plots based on correlation and median absolute deviation (MAD); adjusting colors for heatmaps; aggregate technical replicates; calculate pairwise fold-changes and log fold-changes; compute one- and two-way ANOVA; simplified interface to package 'limma' (Ritchie et al. (2015), ) for moderated t-test and one-way ANOVA; Hamming and Levenshtein (edit) distance of strings as well as optimal alignment scores for global (Needleman-Wunsch) and local (Smith-Waterman) alignments with constant gap penalties (Merkl and Waack (2009), ISBN:978-3-527-32594-8).

Tools for Statistical Disclosure Control in Research Data Centers

Tools for researchers to explicitly show that their results comply to rules for statistical disclosure control imposed by research data centers. These tools help in checking descriptive statistics and models and in calculating extreme values that are not individual data. Also included is a simple function to create log files. The methods used here are described in the "Guidelines for the checking of output based on microdata research" by Bond, Brandt, and de Wolf (2015) < https://cros.ec.europa.eu/system/files/2024-02/Output-checking-guidelines.pdf>.

Article Formats for R Markdown

A suite of custom R Markdown formats and templates for authoring journal articles and conference submissions.

Permutational Group Sequential Test for Time-to-Event Data

Permutational group-sequential tests for time-to-event data based on the log-rank test statistic. Supports exact permutation test when the censoring distributions are equal in the treatment and the control group and approximate imputation-permutation methods when the censoring distributions are different.

A Time Series Database for Official Statistics with R and PostgreSQL

Archive and manage times series data from official statistics. The 'timeseriesdb' package was designed to manage a large catalog of time series from official statistics which are typically published on a monthly, quarterly or yearly basis. Thus timeseriesdb is optimized to handle updates caused by data revision as well as elaborate, multi-lingual meta information.

High Dimensional Categorical Data Visualization

Easy visualization for datasets with more than two categorical variables and additional continuous variables. The package is particularly useful for exploring complex categorical data in the context of pathway analysis across multiple conditions. This package is now in maintenance-only mode and kept for legacy compatibility; for new projects and active development, please use the successor package 'ggdiceplot' (see < https://github.com/maflot/ggdiceplot> and < https://dice-and-domino-plot.readthedocs.io/en/latest/>).

Simulation and Data Analysis for Plant Breeders

Provides tools for simulation of plant breeding programs as described, for example, by Melchinger and Frisch (2023) , prediction of segregation variance (Osthushenrich, Frisch and Herzog (2017) ), genomic prediction (Hofheinz and Frisch (2014) ), linkage disequilibrium based haplotype construction, and planning of marker assisted back crossing programs.

Parametric Time-to-Event Analysis with Variable Incubation Phases

Fit parametric models for time-to-event data that show an initial 'incubation period', i.e. a variable delay phase where no events occur. The delayed Weibull distribution serves as the foundational data model. For parameter estimation, different flavours of maximum likelihood estimation ('MLE') and the method of maximum product of spacings estimation ('MPSE') are implemented. Bootstrap confidence intervals for parameters and significance tests in a two group setting are provided.

Get Data from the 'KOF Datenservice' API

Read Swiss time series data from the 'KOF Data' API, < https://datenservice.kof.ethz.ch>. The API provides macro economic time series data mostly about Switzerland. The package itself is a set of wrappers around the 'KOF Datenservice' API. The 'kofdata' package is able to consume public information as well as data that requires an API token.