K-Means Clustering with Build-in Missing Data Imputation

This k-means algorithm is able to cluster data with missing values and as a by-product completes the data set. The implementation can deal with missing values in multiple variables and is computationally efficient since it iteratively uses the current cluster assignment to define a plausible distribution for missing value imputation. Weights are used to shrink early random draws for missing values (i.e., draws based on the cluster assignments after few iterations) towards the global mean of each feature. This shrinkage slowly fades out after a fixed number of iterations to reflect the increasing credibility of cluster assignments. See the vignette for details.

The Composer of Plots

The 'ggplot2' package provides a strong API for sequentially building up a plot, but does not concern itself with composition of multiple plots. 'patchwork' is a package that expands the API to allow for arbitrarily complex composition of plots by, among others, providing mathematical operators for combining multiple plots. Other packages that try to address this need (but with a different approach) are 'gridExtra' and 'cowplot'.

Generalized Propensity Score Estimation and Matching for Multiple Groups

Implements the Vector Matching algorithm to match multiple treatment groups based on previously estimated generalized propensity scores. The package includes tools for visualizing initial confounder imbalances, estimating treatment assignment probabilities using various methods, defining the common support region, performing matching across multiple groups, and evaluating matching quality. For more details, see Lopez and Gutman (2017) .

Make Multiple 'leaflet' Maps in 'Shiny'

Simplify creating multiple, related 'leaflet' maps across tabs for a 'shiny' application. Users build lists of any polygons, points, and polylines needed for the project, use the map_server() function to assign built lists and other chosen aesthetics into each tab, and the package leverages modules to generate all map tabs.

Multivariate Normal and t Distributions

Computes multivariate normal and t probabilities, quantiles, random deviates, and densities. Log-likelihoods for multivariate Gaussian models and Gaussian copulae parameterised by Cholesky factors of covariance or precision matrices are implemented for interval-censored and exact data, or a mix thereof. Score functions for these log-likelihoods are available. A class representing multiple lower triangular matrices and corresponding methods are part of this package.

Generating Funky Heatmaps for Data Frames

Allows generating heatmap-like visualisations for data frames. Funky heatmaps can be fine-tuned by providing annotations of the columns and rows, which allows assigning multiple palettes or geometries or grouping rows and columns together in categories. Saelens et al. (2019) .

Simultaneous Inference in General Parametric Models

Simultaneous tests and confidence intervals for general linear hypotheses in parametric models, including linear, generalized linear, linear mixed effects, and survival models. The package includes demos reproducing analyzes presented in the book "Multiple Comparisons Using R" (Bretz, Hothorn, Westfall, 2010, CRC Press).

Store and Transfer Amplicon Sequence Data

Stores the data associated with your amplicon sequence analysis. This includes nucleotide sequences, abundance, sample and treatment assignments, taxonomic classifications, asv, otu and phylotype clusters, metadata, trees and various reports. It is designed to facilitate data analysis across multiple R packages with utility functions to read / write from 'mothur', 'qiime2', 'dada2', and 'phyloseq'.

Measuring the Stability of Dimension Reduction and Cluster Assignment in scRNA-Seq Experiments

Provides functions for evaluating the stability of low-dimensional embeddings and cluster assignments in single‑cell RNA sequencing (scRNA‑seq) datasets. Starting from a principal component analysis (PCA) object, users can generate multiple replicates of t‑Distributed Stochastic Neighbor Embedding (t‑SNE) or Uniform Manifold Approximation and Projection (UMAP) embeddings. Embedding stability is quantified by computing pairwise Kendall’s Tau correlations across replicates and summarizing the distribution of correlation coefficients. In addition to dimensionality reduction, 'scStability' assesses clustering consistency using either Louvain or Leiden algorithms and calculating the Normalized Mutual Information (NMI) between all pairs of cluster assignments. For background on UMAP and t-SNE algorithms, see McInnes et al. (2020, ) and van der Maaten & Hinton (2008, < https://github.com/lvdmaaten/bhtsne>), respectively.

Analysis of Alternative Polyadenylation Using 3' End-Linked Reads

A computational method developed for model-based analysis of alternative polyadenylation (APA) using 3' end-linked reads. It accurately assigns 3' RNA-seq reads to polyA sites through statistical modeling, and generates multiple statistics for APA analysis. Please also see Li WV, Zheng D, Wang R, Tian B (2021) .