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Residual Diagnostics for Hierarchical (Multi-Level / Mixed) Regression Models
The 'DHARMa' package uses a simulation-based approach to create readily interpretable scaled (quantile) residuals for fitted (generalized) linear mixed models. Currently supported are linear and generalized linear (mixed) models from 'lme4' (classes 'lmerMod', 'glmerMod'), 'glmmTMB', 'GLMMadaptive', and 'spaMM'; phylogenetic linear models from 'phylolm' (classes 'phylolm' and 'phyloglm'); generalized additive models ('gam' from 'mgcv'); 'glm' (including 'negbin' from 'MASS', but excluding quasi-distributions) and 'lm' model classes. Moreover, externally created simulations, e.g. posterior predictive simulations from Bayesian software such as 'JAGS', 'STAN', or 'BUGS' can be processed as well. The resulting residuals are standardized to values between 0 and 1 and can be interpreted as intuitively as residuals from a linear regression. The package also provides a number of plot and test functions for typical model misspecification problems, such as over/underdispersion, zero-inflation, and residual spatial, phylogenetic and temporal autocorrelation.
Multivariate Normal Mixture Models and Mixtures of Generalized Linear Mixed Models Including Model Based Clustering
Contains a mixture of statistical methods including the MCMC methods to analyze normal mixtures. Additionally, model based clustering methods are implemented to perform classification based on (multivariate) longitudinal (or otherwise correlated) data. The basis for such clustering is a mixture of multivariate generalized linear mixed models. The package is primarily related to the publications Komárek (2009, Comp. Stat. and Data Anal.)
Regression Models for Ordinal Data
Implementation of cumulative link (mixed) models also known as ordered regression models, proportional odds models, proportional hazards models for grouped survival times and ordered logit/probit/... models. Estimation is via maximum likelihood and mixed models are fitted with the Laplace approximation and adaptive Gauss-Hermite quadrature. Multiple random effect terms are allowed and they may be nested, crossed or partially nested/crossed. Restrictions of symmetry and equidistance can be imposed on the thresholds (cut-points/intercepts). Standard model methods are available (summary, anova, drop-methods, step, confint, predict etc.) in addition to profile methods and slice methods for visualizing the likelihood function and checking convergence.
Fitting Mixed Models with Known Covariance Structures
The main functions are 'emmreml', and 'emmremlMultiKernel'. 'emmreml' solves a mixed model with known covariance structure using the 'EMMA' algorithm. 'emmremlMultiKernel' is a wrapper for 'emmreml' to handle multiple random components with known covariance structures. The function 'emmremlMultivariate' solves a multivariate gaussian mixed model with known covariance structure using the 'ECM' algorithm.
Linear Mixed Models for Complex Survey Data
Linear mixed models for complex survey data, by pairwise composite likelihood, as described in Lumley & Huang (2023)
Functional Linear Mixed Models for Densely Sampled Data
Estimation of functional linear mixed models for densely sampled data based on functional principal component analysis.
Power Analysis for Generalised Linear Mixed Models by Simulation
Calculate power for generalised linear mixed models, using
simulation. Designed to work with models fit using the 'lme4' package.
Described in Green and MacLeod, 2016
Data sets from "SAS System for Mixed Models"
Data sets and sample lmer analyses corresponding to the examples in Littell, Milliken, Stroup and Wolfinger (1996), "SAS System for Mixed Models", SAS Institute.
Inference of Linear Mixed Models Through MM Algorithm
The main function MMEst() performs (Restricted) Maximum Likelihood in a variance component mixed models using a Min-Max (MM) algorithm (Laporte, F., Charcosset, A. & Mary-Huard, T. (2022)
Linear Mixed Models
It implements Expectation/Conditional Maximization Either (ECME) and rapidly converging algorithms as well as Bayesian inference for linear mixed models, which is described in Schafer, J.L. (1998) "Some improved procedures for linear mixed models". Dept. of Statistics, The Pennsylvania State University.