Computing Weighted Topological Overlaps (wTO) & Consensus wTO Network

Computes the Weighted Topological Overlap with positive and negative signs (wTO) networks given a data frame containing the mRNA count/ expression/ abundance per sample, and a vector containing the interested nodes of interaction (a subset of the elements of the full data frame). It also computes the cut-off threshold or p-value based on the individuals bootstrap or the values reshuffle per individual. It also allows the construction of a consensus network, based on multiple wTO networks. The package includes a visualization tool for the networks. More about the methodology can be found at .


Reference manual

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1.6.3 by Deisy Morselli Gysi, 2 years ago

Browse source code at

Authors: Deisy Morselli Gysi , Andre Voigt , Tiago Miranda Fragoso , Eivind Almaas and Katja Nowick.

Documentation:   PDF Manual  

GPL-2 license

Imports data.table, igraph, magrittr, plyr, parallel, som, visNetwork, reshape2, shiny

Suggests knitr, rmarkdown

Suggested by CoDiNA, EGAnet.

See at CRAN