Tilted Bootstrap

Creates simulated clinical trial data with realistic correlation structures and assumed efficacy levels by using a tilted bootstrap resampling approach. Samples are drawn from observed data with some samples appearing more frequently than others. May also be used for simulating from a joint Bayesian distribution along with clinical trials based on the Bayesian distribution.


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Reference manual

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install.packages("tboot")

0.2.0 by Nathan Morris, 9 days ago


https://github.com/njm18/tboot


Report a bug at https://github.com/njm18/tboot/issues


Browse source code at https://github.com/cran/tboot


Authors: Nathan Morris [aut, cre] , William Michael Landau [ctb] , Eli Lilly and Company [cph]


Documentation:   PDF Manual  


GPL-3 license


Imports stats, quadprog, kernlab

Suggests knitr, rmarkdown, testthat, MASS, ggplot2


See at CRAN