surrosurv
Evaluation of Failure Time Surrogate Endpoints in Individual Patient Data Meta-Analyses
Provides functions for the evaluation of
surrogate endpoints when both the surrogate and the true endpoint are failure
time variables. The approaches implemented are:
(1) the two-step approach (Burzykowski et al, 2001)
Evaluation of Failure Time Surrogate Endpoints in Individual Patient Data Meta-Analyses
Description
Provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the two-step approach (Burzykowski et al, 2001) DOI:10.1111/1467-9876.00244 with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of log-hazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM.
News
Changes in version 1.1.23 (2017-07-13)
- new function simData.gh() to generate data from Gumbel-Hougaard copula
Changes in version 1.1.15 (2017-04-25)
- fixed minor issue in prediction function for adjusted copula models
Changes in version 1.1.14 (2017-04-06)
- fixed issue in prediction intervals for mixed Poisson models
Changes in version 1.1.13 (2017-03-28)
- fixed issue in prediction intervals for adjusted copula models
Changes in version 1.1.12 (2017-03-02)
- loocv() now also returns the values of kTau and R2 estimated in each (N-1) fold
Changes in version 1.1.10 (2017-02-27)
- fixed issues with loocv when few trials (added controls)
- added data 'gastadj'
- added twoStage parameter to surrosurv for Shih and Louis (1995) approach to copula estimation
Changes in version 1.1.4 (2016-12-06)
- added paper manuscript as vignette('surrosurv')
Changes in version 1.1 (2016-11-09)
- Poisson models can be fitted each separately
################################################################################
Changes in version 0.1.1 (2016-09-28)
- fixed examples for poissonize()
Changes in version 0.1.0 (First Complete version, 2016-09-27)
- new function loocv() (with print() and plot() functions) to compute leave-one-out cross-validation
################################################################################
Changes in version 0.0.15 (2016-09-23)
- new function ste() to compute the surrogate threshold effect
- plot.sussosurv() can now show prediction intervals and the STE
Changes in version 0.0.11 (2016-08-12)
- predict and plot for class sussosurv
Changes in version 0.0.10 (2016-08-01)
- kkt2 convergence criteria corrected from positive determinant to positive min eigenvalue
Changes in version 0.0.9 (2016-07-28)
- bugfix in Poisson method, which did not return results because of mispelled model name
Changes in version 0.0.7 (2016-07-25)
- the Kendall's tau for copulas is now initialized using the SurvCorr package (much faster)
Changes in version 0.0.6 (2016-07-22)
- added the function convals(), giving the values of the max abs gradient and the min eigenvalue of the variance-covariance matrix of the random treatment effects
- the function convergence() uses explicit computation provided by covals(), instead of using the function optimx in the package optimx