surrosurv
Evaluation of Failure Time Surrogate Endpoints in Individual Patient Data Meta-Analyses
Provides functions for the evaluation of
surrogate endpoints when both the surrogate and the true endpoint are failure
time variables. The approaches implemented are:
(1) the two-step approach (Burzykowski et al, 2001)
surrosurv
Evaluation of Failure Time Surrogate Endpoints in Individual Patient Data Meta-Analyses
Description
Provides functions for the evaluation of surrogate endpoints when both the surrogate and the true endpoint are failure time variables. The approaches implemented are: (1) the two-step approach (Burzykowski et al, 2001) DOI:10.1111/1467-9876.00244 with a copula model (Clayton, Plackett, Hougaard) at the first step and either a linear regression of log-hazard ratios at the second step (either adjusted or not for measurement error); (2) mixed proportional hazard models estimated via mixed Poisson GLM.