Bootstrap Imputation for Single-Cell RNA-Seq Data

Given a log-transformed expression matrix and list of informative genes: subsample informative genes, cluster samples using shared nearest neighbors clustering, estimate missing expression values with the distribution mean of means extrapolated from these cell clusterings, and return an imputed expression matrix. See Tracy, S., Yuan, G.C. and Dries, R. (2019) for more details.


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1.0.3 by Sam Tracy, a year ago

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Authors: Sam Tracy & Ruben Dries

Documentation:   PDF Manual  

GPL-2 | GPL-3 license

Imports data.table, dbscan, igraph, irlba, Matrix, methods, parallel, reticulate

Depends on utils

Suggests knitr, rmarkdown

See at CRAN