Repertoire Dissimilarity Index

Methods for calculation and visualization of the Repertoire Dissimilarity Index. Citation: Bolen and Rubelt, et al (2017) .


The RDI package is part of the Immcantation analysis framework for Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) and provides an methods for visualizing and calculating the Repertoire Dissimilarity Index (RDI).

The Repertoire Dissimilarity Index is a non-parametric method for directly comparing sequencing repertoires, with the goal of rigorously quantifying differences in V, D, and J gene segment utilization. This method uses a bootstrapped subsampling approach to account for variance in sequencing depth, and, coupled with a data simulation approach, allows for direct quantification of the average variation between repertoires.


For help and questions please contact the Immcantation Group or use the issue tracker.


Version 1.0.0: May 1, 2018

Internal changes and extra documentation for submission to CRAN.

Some variable names changed for consistency:

  • n_iter changed to nIter
  • label.ladder changed to labelLadder
  • line.col changed to lineCol
  • fill.col changed to fillCol

Version 0.9.0: October 12, 2016

Initial public release.

Reference manual

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1.0.0 by Christopher Bolen, 3 years ago

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Browse source code at

Authors: Christopher Bolen [aut, cre] , Florian Rubelt [aut] , Jason Vander Heiden [aut]

Documentation:   PDF Manual  

CC BY-SA 4.0 license

Imports beanplot, gplots, pdist, stringr

Suggests knitr, ggplot2

See at CRAN