Repeated Measurement Design for Phase I Clinical Trial

Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) .


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install.packages("phase1RMD")

1.0.8 by Jun Yin, a year ago


Browse source code at https://github.com/cran/phase1RMD


Authors: Jun Yin , Yu Du , Sumithra Mandrekar


Documentation:   PDF Manual  


GPL (>= 2) license


Imports arrayhelpers

Depends on coda, boot, rjags, mvtnorm, ggplot2

Suggests R2WinBUGS, BiocParallel


Imported by phase1PRMD.


See at CRAN