Repeated Measurement Design for Phase I Clinical Trial

Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) .


Reference manual

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1.0.9 by Jun Yin, a year ago

Browse source code at

Authors: Jun Yin , Yu Du , Sumithra Mandrekar

Documentation:   PDF Manual  

GPL (>= 2) license

Imports arrayhelpers

Depends on coda, boot, rjags, mvtnorm, ggplot2

Suggests BiocParallel

See at CRAN