Model-Based Dose-Escalation Trials

User-friendly Shiny apps for designing and evaluating phase I cancer clinical trials, with the aim to estimate the maximum tolerated dose (MTD) of a novel drug, using a Bayesian decision procedure based on logistic regression.


News

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modest package news

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Please report bugs and unexpected behaviour to Philip Pallmann [email protected]

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Version 0.3-1 (3 November 2017)

  • Minor change to simulations plot.
  • Removed 'DT' from Imports.
  • Removed MathJax elements.
  • Updated maintainer email address.

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Version 0.3 (26 September 2017)

  • 'Show another run' button to generate multiple simulated examples.
  • Download button for detailed simulation results in a csv file.
  • Minor changes to the appearance of various graphs.

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Version 0.2 (4 August 2017)

  • New spreadsheet interface for manual data entry into 'Design' module.
  • Informative error messages added.
  • Pointwise 95% confidence bands added to dose-toxicity curves.
  • New stopping rule based on the number of consecutive patients receiving the same dose.
  • Two vignettes added.
  • Various minor bug fixes and improvements.

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Version 0.1 (26 June 2017)

  • Initial release.

Reference manual

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install.packages("modest")

0.3-1 by Philip Pallmann, a year ago


Report a bug at https://github.com/PhilipPallmann/modest/issues/


Browse source code at https://github.com/cran/modest


Authors: Philip Pallmann [aut, cre] , Fang Wan [aut]


Documentation:   PDF Manual  


GPL-2 license


Imports knitr, rhandsontable, shiny, shinyBS


See at CRAN