Integrating Multiple Modalities of High Throughput Assays Using Item Response Theory

Provides a systematic framework for integrating multiple modalities of assays profiled on the same set of samples. The goal is to identify genes that are altered in cancer either marginally or consistently across different assays. The heterogeneity among different platforms and different samples are automatically adjusted so that the overall alteration magnitude can be accurately inferred. See Tong and Coombes (2012) .


Reference manual

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1.0.5 by Kevin R. Coombes, 2 years ago

Browse source code at

Authors: Pan Tong , Kevin R Coombes

Documentation:   PDF Manual  

Apache License (== 2.0) license

Imports mclust, MASS, abind

Depends on ltm, foreach, doParallel

Suggests KernSmooth

See at CRAN