Inferring the Topology of Omics Data

Infers a topology of relationships between different datasets, such as multi-omics and phenotypic data recorded on the same samples. We based this methodology on the RV coefficient (Robert & Escoufier, 1976, ), a measure of matrix correlation, which we have extended for partial matrix correlations and binary data (Aben et al., 2018, ).


iTOP 1.0.2

Some slight changes to the vignette and adding support for using n x 1 matrices.

iTOP 1.0.1

The iTOP manuscript is now on bioRxiv! Adding the DOI in all relevant places.

iTOP 1.0.0

First release version!

Reference manual

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1.0.2 by Nanne Aben, 3 years ago

Browse source code at

Authors: Nanne Aben

Documentation:   PDF Manual  

GPL-2 license

Imports Matrix, corpcor

Suggests knitr, rmarkdown, NMF, pcalg, Rgraphviz

See at CRAN