Group Sequential Refined Secondary Boundary

A gate-keeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks. Computations related to group sequential primary and secondary boundaries. Refined secondary boundaries are calculated for a gate-keeping test on a primary and a secondary endpoint in a group sequential design with multiple interim looks. The choices include both the standard boundaries and the boundaries using error spending functions. See Tamhane et al. (2018), "A gatekeeping procedure to test a primary and a secondary endpoint in a group sequential design with multiple interim looks", Biometrics, 74(1), 40-48.


Reference manual

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install.packages("gsrsb")

1.2.1 by Jiangtao Gou, 3 years ago


Browse source code at https://github.com/cran/gsrsb


Authors: Jiangtao Gou [cre, aut] , Fengqing (Zoe) Zhang [aut]


Documentation:   PDF Manual  


GPL-3 license


Imports stats, mvtnorm, ldbounds, xtable


See at CRAN